Describe the presentation, get a prioritized differential in three tiers: must-not-miss, most likely, and worth considering, each grounded in your patient’s actual data, plus a targeted workup.
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The dreaded rounds question is not "what does the patient have." It is "what is your differential," followed by silence while you try to rank ten diagnoses in your head. The Differential Generator turns any presentation, from dyspnea with orthopnea to painless jaundice, into a structured, prioritized differential built the way internists actually think.
Give it the chief complaint and HPI, plus whatever vitals, exam findings, and labs you have. It returns three tiers: the must-not-miss diagnoses that would harm the patient if delayed, with exactly what it takes to rule each out; the most likely diagnoses ranked by probability, with the specific features from your patient supporting and arguing against each; and the less likely diagnoses worth keeping on the list.
It closes with a clinical summary that connects the dots and a workup list split into send-now, send-with-admission, and consider-if-negative, each test justified against this specific patient. Then you can push further: drill one diagnosis, add new data, or ask it to pimp you on the case.
Chief complaint and HPI, plus any vitals, exam findings, labs, or imaging you already have. Partial data is fine.
Must-not-miss, most likely, and less likely diagnoses, each with what fits, what confirms, and what rules out.
A targeted test list with a one-line justification per test, prioritized by what needs to go now.
Three tiers: must-not-miss diagnoses with explicit rule-out criteria, most likely diagnoses ranked with supporting and opposing features from your patient, and less likely diagnoses with one line on what would move them up.
It reasons out loud like an attending on rounds: why each diagnosis fits this patient, which findings argue against it, and how the pieces connect. The goal is teaching you the framework, not handing you a list.
Yes. Feed it the new troponin, the CT read, or the culture result and it re-ranks the differential and tells you what changed.
No. It is a learning and prep tool for students and trainees. Clinical decisions belong to the licensed team caring for the patient.
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